Good idea for a speedrun? House of the Dead 2/3 for PC would be fun. I was thinking doing them in Time Trial Mode would be best, as then the timings done for you.
Time trial mode would probably be the only way for it to be considered a speedrun, unless killing faster progressed the main game faster (bosses is the only place I could see where). Other than that I think it would be pretty great to watch someones shooting skills.
A comparable run would be the StarFox 64 runs, also a rail gunner. Now this game, as I remember it there's no time reward for killing faster, *but* I think there might be a time penalty for getting hit (slashes, thrown axes/barrels). I don't remember so much. Also to note are the alternate paths, depending on which NPCs you save or not. But yes, I think this could be done. Watching someone machinegunning through this game could be fun.
You get extra time for killing faster in the speedrun section, and you lose time for getting hit by all enemies. Would that still be OK, using the games time as the indication of speed?