If you'd be willing to use one of the mods from NMA that fixes the game, you could stream it. I was able to stream it off a GOG install + Fallout fixit patch with OBS.
However, depending on what your goals are with running the game, or submitting it to SDA, then I can understand not wanting to mod it at all.
However, depending on what your goals are with running the game, or submitting it to SDA, then I can understand not wanting to mod it at all.