Jack of all Trades
Quote from Fragmaster01:
I saw a video of Chocolate Milk + Brimstone. It's basically the charged laser with a reload speed equal to normal tears.
Getting those as your first two items is less likely than just getting Fetus, which is already pretty taxing.
Even then if you one shot every monster in the room (e.g. clump in the middle) you're only as fast as Fetus because you won't have to stop moving at all. If the enemies are spread out and you have to stick around then you lose time because Fetus will already be in the next room. If you have to fight an annoying multistage mini-boss (or multiples thereof) in the womb/sheol you're losing time again, although I suppose you could save bombs for such an occasion. The Brimstone item is a LOT easier/safer to use though. The fact it pierces all obstacles and enemies and gives max damage and only costs a single heart is so ridiculous I wonder if it'll be nerfed in a future patch. Or other devil items will be price adjusted (e.g. +damage items that cost 2 hearts going to 1, ditto with the nail).
Plus you'll lose time before you get the Brimstone item from the first boss devil room since you'll just have wimpy tears for the first basement. There are a couple obnoxious room setups involving catwalks in the caves where the Brimstone might be faster than the Fetus though.