One hand is enough.
Quote from mikwuyma:
Vanquish: Yeah I'm aware this is fast-paced third-person shooter. My biggest concern about a casual run is how the enemies get steamrolled in a run. Let's be honest, they don't pose a great threat in a casual run. I'm not sure if the movement would outweigh the challenge the enemies put up, which is a concern since there are plenty of parts where you have to fight enemies in Vanquish.
Yes, I will concede that there is overall a low risk of death in a casual difficulty run. This does NOT however, mean that combat is reduced to a leisurely relaxed affair. A high degree of skill and knowledge of the game goes into completing battles quickly and effectively, with many of the one-cycles and QTE skips being fairly tight on timing and difficult to pull off. Resource management for battles is a huge factor, and knowing when to use what weapons/grenades is paramount to speedrunning effectively. A certain intensity is afforded by how quickly singular enemies can be dispatched when played well, allowing for fast movement and routing within each battle. Casual difficulty may not FORCE high-level play, but when advanced techniques are applied to it the combat becomes an entertaining and explosive frenzy.
I assure you that the combat is by no means a trivial matter in my run, and the difficulty setting permits it more to actually be a speedrun instead of simply a timed playthrough.